After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)).

Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2 2.2% (50/2317) in patients with peri-operative SARS-CoV-2 1.6% (15/953) in patients with recent SARS-CoV-2 and 1.0% (11/1148) in patients with previous SARS-CoV-2. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery) recent (1-6 weeks before surgery) previous (≥7 weeks before surgery) or none. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. Patients from all surgical specialties were included.

We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients.

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